Sunday the San Francisco 49ers will visit Ralph Wilson Stadium and try to be the first Pacific Time Zone team this season to win a game in the east. Odds makers are calling the Bills home favorites as the Niners come to town. NFL betting odds have Buffalo at -6.5 with the total sitting at 42.5.

Western teams playing with a three-hour time change are 0-14 this year. They average 15.8 points scored and 26.9 points against.

Coming off a 54-31 victory over Kansas City a week ago, the Bills have developed some swagger back on offense. Now they need to keep it going to stay in the playoff picture. At 6-5, Buffalo will need to get on a little run to end their eight season playoff drought.

"We know the position that we're in," wide receiver Josh Reed said. "It's going to be tough, but the positive is that we still have a chance and we're still right there. We know what we have to do."

The 49ers, and head coach Mike Singletary are trying to change their attitude and are trying to learn how to win. San Francisco is guaranteed to finish with their sixth straight season without a winning record, Singletary realizes he has limited time to make changes.

One change on the defense will be the playing time of linebacker Manny Lawson. Lawson missed the final 14 games of last season with a torn ligament in his left knee, and he strained his hamstring last month.

"He's had to work toward that," Singletary said. "It's not like Manny has been doing great all year, and all of a sudden, 'Why isn't he playing?' We're trying to get him on the field. The last three weeks or so, he's really been coming on. You can see the confidence."

Look for the Bills to win this one. Take Buffalo and give the 6.5 points.